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and induces a significant increase in the percentage of polyploid cells
Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1
BAY11-7082 also reversibly activates MAPK signaling and induces apoptosis of leukemic T cell and B-cell lymphoma cell lines
2-2 µM concentration in vitro and cellular assays
AGI-6780 - Mutant IDH2 Inhibitor. CAS# 1432660-47-3 60218 and induces a significant increaseAGI 6780, CAS No. 1432660 47 3, is a potent and selective IDH2 inhibitor. AGI 6780 inhibits the tumor associated mutant IDH2 R140Q. Treatment with AGI 6780 induced differentiation of TF 1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2 R140Q could have potential applications as a differentiation therapy for cancer. Product information CAS Number: 1432660 47 3 Molecular Weight: 481. 51