![(±)-J 113397 imebutine maleate Smiles: C[C@@H]1CN(CCN1C(=O)[C@H]1C[C@@H]1C1=CC=C(C=C1)C(N)=O)C1CCC1](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M22413_1635323702.gif?v=1635323704)
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Smiles: C[C@@H]1CN(CCN1C(=O)[C@H]1C[C@@H]1C1=CC=C(C=C1)C(N)=O)C1CCC1
Solubility: DMSO : 100 mg/mL (200
InChiKey: HMSFWLUZEDMXMM-UHFFFAOYSA-N
2 mg/kg) inhibits 125I-oCRF binding by >80% in rats
(±)-J 113397 imebutine maleate Smiles: C[C@@H]1CN(CCN1C(=O)[C@H]1C[C@@H]1C1=CC=C(C=C1)C(N)=O)C1CCC1() J 113397 is a potent and selective non peptidyl antagonist of ORL1 receptor, with a Ki value of 1. 8 nM for cloned human ORL1 . The ORL1 receptor is a G protein coupled. It is structurally related to the opioid receptors. The heptadecapeptide nociceptin orphanin FQ is the endogenous ligand . In CHO ORL1 cells, nociceptinr orphanin FQ dose dependently suppressed the accumulation of cyclic AMP stimulated by forskolin with an EC value of 0. 22 0. 011
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