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DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid
5(4):355-7
Omeprazole (H 16868) virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1
Chemical Name: 2-{[5-hydroxy-7-(hydroxymethyl)-1H
Lysine-specific Demethylase Inhibitor (1C) orine hydrochloride DC260126 dose-dependently inhibits GPR40-mediated Ca2+Lysine specific Demethylase Inhibitor (1C) is a lysine specific demethylase inhibitor. Lysine specific demethylase 1 (LSD1) is the first of several protein lysine demethylases identified. Through a FAD dependent oxidative reaction, LSD1 could specifically remove histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor, LSD1 alters its substrates to H3K9me2. The LSD1 complex regulates a coordinated histone modification
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