N-Acetyl calicheamicin - enediyne antitumor antibiotic. CAS# 108212-76-6 Size:2mg solid Exposure of human Jurkat T

Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3

]tetradec-7-en-13-one

InChi: InChI=1S/C24H23N3O3S/c1-14-8-9-21(15(2)12-14)30-11-10-27-16(3)18(17-6-4-5-7-20(17)27)13-19-22(28)25-24(31)26-23(19)29/h4-9

(2015) Epigenomics

N-Acetyl calicheamicin - enediyne antitumor antibiotic. CAS# 108212-76-6 Size:2mg solid Exposure of human Jurkat TN Acetyl calicheamicin, CAS No. 108212 76 6, is a derivative of calicheamicin, and is a potent enediyne antitumor antibiotic. Calicheamicins target DNA and cause strand scission. Calicheamicins bind with DNA in the minor groove, wherein they then undergo a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1, 4 didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA,