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CAS Number: 1227158-85-1
2533/chimia
inhibition of DDX3 by RK-33 promotes tumor regression
Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells
GSK-2606414 - CAS# 1337531-36-8 0435 CAS Number: 1227158-85-1GSK 2606414, CAS No. 1337531 36 8, is an orally available, potent, and selective PERK inhibitor. GSK 2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR) like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival
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