Pralatrexate - CAS# 146464-95-1 arin Le Stunff H

Le Stunff H

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

149(5):1060-1072

InChiKey: GLVAUDGFNGKCSF-UHFFFAOYSA-N

Pralatrexate - CAS# 146464-95-1 arin Le Stunff HPralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier 1 (RFC 1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC 1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors;