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Smiles: CC1=CC(=CC=N1)C1C=CC(CC(=O)NC2C=CC(=CC=2)C2=CN=CC=C2)=CC=1
57(1):31-46
Su-11274 inhibits the HGF-induced cell growth with IC50 of 3
Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis
Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 size:10mg solid Smiles: CC1=CC(=CC=N1)C1C=CC(CC(=O)NC2C=CC(=CC=2)C2=CN=CC=C2)=CC=1Wnt C59, CAS No. 1243243 89 1, is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane bound O acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV WNT1 transgenic mice model while
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