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Inhibitor is a novel stearoyl-CoA desaturase1 (SCD1) inhibitor
4-tetrahydroisoquinolin-2-yl]-N-methyl-2-phenylacetamide hydrochloride
1986 Jun 12-18
Formula: C32H40Br2N4
Dehydrocorydaline 02 Hydrochloride Inhibitor is a novel stearoyl-CoADehydrocorydaline (13 Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W. T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl 2; activates caspase 7, caspase 8, and inactivates PARP. Dehydrocorydaline elevates p38 MAPK activation. Anti inflammatory and anti cancer activities. Dehydrocorydaline shows strong anti malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P.
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