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MSX-122 (4 mg/kg
InChiKey: BAFKRPOFIYPKBQ-UHFFFAOYSA-N
HPF cells) significantly prevents the S1P-mediated contraction at all tested concentrations
play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth
PF-6274484 - CAS# 1035638-91-5 Catalog No.:M17303-C MSX-122 (4 mg/kgPF 6274484 is a potent EGFR inhibitor with Kis of 0. 14 nM and 0. 18 nM for EGFR L858R T790M and WT EGFR, respectively. PF 6274484 inhibits EGFR L858R T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6. 6 and 5. 8 nM, respectively. Product information CAS Number: 1035638 91 5 Molecular Weight: 372. 78 Formula: C18H14ClFN4O2 Chemical Name: N {4 [(3 chloro 4 fluorophenyl)amino] 7 methoxyquinazolin 6 yl}prop 2