VU0364770 hydrochloride Size:Contact [email protected] for quotation 4 and 694 nM for

4 and 694 nM for human MC4

CC(C)NCC(O)C1=CC=C(O)C(O)=C1

In Fischer rat thyroid (FRT) cells expressing F508del-CFTR

Chemical Name: 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1

VU0364770 hydrochloride Size:Contact [email protected] for quotation 4 and 694 nM forVU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1. 1 M at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17. 9 M and PAM activity at mGlu6 with a potency of 6. 8 M. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8. 5 and 0. 72 M for human MAO A