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N-type calcium channel blocker-1 shows good activities in the acetic acid anti-writhing model (ED50=4 mg/kg
CG-806 6-Amine N-type calcium channel blocker-1 showsCG 806 is a pan FLT3 BTK Multi Kinase inhibitor. CG 806 (CG'806) is a small molecule multi kinase inhibitor against FLT3 and BTK kinases that is under development to treat FLT3 driven AML. CG 806 exerts potent picomolar IC50 anti proliferative activity against human AML cells and against Ba F3 mouse AML cells with FLT3 ITD mutations (about 50 to 250 fold higher activity compared to quizartinib or gilteritinib). Specifically, compared to second