CH5424802 Catalog No.:M10732-2 Gmeiner WH

Gmeiner WH

Smiles: CC1=CC=C(C=N1)C1=NC=C(Cl)C=C1C1C=CC(=CC=1)S(C)(=O)=O

Chemical Name: (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)propanoic acid

48(12):621-5

CH5424802 Catalog No.:M10732-2 Gmeiner WHAlectinib, also known as AF802, or CH5424802 or RO5424802, is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4 ALK fusion and anaplastic large cell lymphoma (ALCL) cells expressing NPM ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which