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Vatalanib dihydrochloride Catalog No.:M10925-2 Smiles: CCN(CCOC1C=CC(=CC=1)C(=C(Cl)C1C=CC=CC=1)C1C=CC=CC=1)CC

SKU: 60160773867

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Description

Smiles: CCN(CCOC1C=CC(=CC=1)C(=C(Cl)C1C=CC=CC=1)C1C=CC=CC=1)CC

InChi: InChI=1S/C12H14N4O3

Cilomilast and (R)-rolipram are equipotent at suppressing LPS-induced TNF-α formation with -log (IC50) of 7

It induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells

Vatalanib dihydrochloride Catalog No.:M10925-2 Smiles: CCN(CCOC1C=CC(=CC=1)C(=C(Cl)C1C=CC=CC=1)C1C=CC=CC=1)CCVatalanib, also known as PTK787, is an orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet derived growth factor (PDGF) receptor, c Kit, and c Fms. Product

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