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also known as WAY-252623
Chemical Name: (6S)-5
ME-401(PWT-143) is a potent and selective inhibitor of P110δ with IC50 of 8
CAS Number: 1404562-17-9
(S)-Lisofylline Catalog No.:M22422-C also known as WAY-252623Lisofylline (LSF) is a potent anti inflammatory agent. LSF is a chiral metabolite of pentoxifylline . Pentoxifylline is exclusively reduced to (S) LSF in the cytosol when metabolized by isolated human liver cells . In vitro: Lisofylline preserved cell insulin secretion and inhibited DNA damage of islets in the presence of IL 1 . Simultaneous application of LSF and cytokines to INS 1 cells restored insulin secretion, mitochondrial membrane potential,
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