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It decreases cellular levels of H3K27me3 with an EC50 of 70 nM
InChi: InChI=1S/C21H15Cl2FN4O/c1-11-8-13(6-7-17(11)24)26-21-25-10-12-9-14(20(29)28(2)19(12)27-21)18-15(22)4-3-5-16(18)23/h3-10H
CAS Number: 1469750-46-6
InChiKey: QQRFLGRIDNNARB-UHFFFAOYSA-N
MK-4101 Size:Contact [email protected] for quotation It decreases cellular levels ofMK 4101 is a Smoothened (SMO) antagonist (IC50 of 1. 1 M for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC50 of 1. 5 M for mouse cells; IC50 of 1 M for KYSE180 oesophageal cancer cells). MK 4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis. Product information CAS Number: 935273 79 3 Molecular Weight: 493. 47 Formula: C24H24F5N5O Chemical Name: 5 (3,3 difluorocyclobutyl) 3