SBI-0206965 - Autophagy Kinase ULK1 Inhibitor. CAS# 1884220-36-3 0129 Epub 2012 Oct 15

Name: SBI-0206965 - Autophagy Kinase ULK1 Inhibitor. CAS# 1884220-36-3 0129 Epub 2012 Oct 15
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Description

Epub 2012 Oct 15

Differentiation from protein kinase c isoenzymes

28)/t13-/m0/s1

Chemical Name: (2-(phenylamino)-1

SBI-0206965 - Autophagy Kinase ULK1 Inhibitor. CAS# 1884220-36-3 0129 Epub 2012 Oct 15SBI 0206965, CAS No. 1884220 36 3, is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI 0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1 mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI 0206965 greatly synergized with mechanistic target

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