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the trithorax-like family of SET1 methyltransferase
Like the parent compound
Scheuermann TH
[Vemurafenib (Zelboraf) in the therapy of melanoma]
IWR-1 - CAS# 1127442-82-3 60189 the trithorax-like family of SET1IWR 1, also known as IWR 1 endo, CAS No. 1127442 82 3, is a an inhibitor of the Wnt signaling cascade through inhibiting TNKSs, binding only to the adenosine binding site. IWR 1 inhibits epithelial mesenchymal transition of colorectal cancer cells through suppressing Wnt catenin signaling as well as survivin expression. IWR 1 inhibits cell proliferation and EMT even in the presence of TNF induced cancer cell stimulation. IWR 1 also significantly
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