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ZCL278 reduces the perinuclear accumulation of active Cdc42 in contrast to NSC23766
1062368-24-4
ATB-346 may therefore be an attractive agent for chemoprevention of colon cancer
Formula: C11H10N4O
GSK-LSD1 - LSD1 Inhibitor. CAS# 2102933-95-7 0073 ZCL278 reduces the perinuclear accumulationGSK LSD1, CAS No. 2102933 95 7, is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i. e. LSD2, MAO A, MAO B). GSK LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Product
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