AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid 66(7):2059

Name: AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid 66(7):2059
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SKU: 63796904102
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SKU: 63796904102

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Description

66(7):2059

Formula: C17H11Cl3N2O3

MordmÃ¼ller B

104(7):1116-25

AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid 66(7):2059AZD8055, CAS No. 1009298 09 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 0. 8 nM). It has >1, 000 fold selectivity against all PI3K isoforms (, , , ) and other members of the PI3K like kinase family (ATM and DNA PK). It has no significant activity against a panel of 260 kinases at concentrations up to 10 M. AZD8055 inhibits the phosphorylation of mTORC1 downstream targets (p70S6K and 4E BP1) as well as phosphorylation of

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