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Smiles: CP(O)(=O)C(C1=CSC2=CC=C(Cl)C=C12)C(=O)N/C=C/C1C=C(F)C(F)=CC=1
4-tetrahydropyrimidin-1-yl)-3
Mahanine (25 µM
Gelseminic acid
Taletrectinib free base - CAS# 1505514-27-1 Catalog No.:M16463-C Smiles: CP(O)(=O)C(C1=CSC2=CC=C(Cl)C=C12)C(=O)N/C=C/C1C=C(F)C(F)=CC=1Taletrectinib (DS 6051b) free base is a potent, orally active, and new generation selective ROS1 NTRK inhibitor. Taletrectinib free base potently inhibits recombinant ROS1, NTRK1, and NTRK3 with IC50s of 0. 207, 0. 622, 2. 28, and 0. 98 nM, respectively. Taletrectinib free base also inhibits ROS1 G2032R and other Crizotinib resistant ROS1 mutants. Product information CAS Number: 1505514 27 1 Molecular Weight: 405. 47 Formula: C23H24FN5O Chemical Name:
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