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In HEK-293 cells
Sitagliptin has been shown to inhibit DPP-4 activity by > 90% within 1-2 h of administration
Pomalidomide4alkylC4
Pre-treatment with 10 μM inhibits migration to a significantly greater extent than the lower dose in both assays
Aprepitant erin HCl In HEK-293 cellsAprepitant is a small molecule, high affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P induced emesis. This agent has little or no affinity for serotonin type 3 (5 HT3), dopamine, and corticosteroid receptors.
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