TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 InChi: InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4

InChi: InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4

2-dihydroquinoline-3-carboxamido)acetic acid

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

NLG919 was used at 10 µM final concentration in various in vitro assays

TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 InChi: InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4TAK 243 (MLN7243), CAS No. 1450833 55 2, is a potent, selective and cell permeable small molecule inhibitor of the ubiquitin activating enzyme (UAE) at nM range. The ubiquitin activating enzymes, found more active in cancer cells than in normal healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via proteasome. TAK 243 treatment caused depletion of cellular ubiquitin conjugates, resulting in