Itraconazole-d5 oxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside 6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2

6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2

InChiKey: LNELWUPBSLZUIQ-MQMHXKEQSA-N

isolated from the sclerotium of Poria cocos

Smiles: FC1=C2NC(CNC3=NC(=NC4=C(C=NN34)C3CC3)N3CCNCC3)=NC2=CC=C1F

Itraconazole-d5 oxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside 6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2Itraconazole d5 (R51211 d5) is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14 demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Product information CAS