SKF-96365 hydrochloride Size:2mg solid Suppression of Plk1 in vivo

Suppression of Plk1 in vivo by using GSK461364 results in mitotic arrest with aberrant mitotic figures consisting of monopolar or collapsed mitotic spindles

It first became available in Europe in 1984

C2HF3O2/c1-16-68(10)111(135(222)154-56-102(192)151-57-103(193)160-94(61-183)119(206)153-59-105(195)159-93(50-101(148)191)139(226)180-42-26-34-96(180)133(220)163-81(33-23-25-41-143)121(208)177-112(71(13)185)137(224)157-70(12)116(203)165-89(49-100(147)190)130(217)175-110(67(8)9)140(227)181-43-27-35-97(181)134(221)164-83(37-39-99(146)189)123(210)179-114(73(15)187)141(228)229)176-122(209)82(36-38-98(145)188)162-125(212)85(45-65(4)5)167-126(213)87(47-75-54-150-79-31-21-20-30-77(75)79)171-138(225)113(72(14)186)178-131(218)90(51-106(196)197)158-104(194)58-152-118(205)84(44-64(2)3)166-132(219)95(62-184)173-120(207)80(32-22-24-40-142)161-115(202)69(11)156-124(211)86(46-74-28-18-17-19-29-74)168-127(214)88(48-76-55-149-63-155-76)169-128(215)91(52-107(198)199)170-129(216)92(53-108(200)201)172-136(223)109(66(6)7)174-117(204)78(144)60-182

Formula: C15H10O7

SKF-96365 hydrochloride Size:2mg solid Suppression of Plk1 in vivoSKF 96365 hydrochloride is a potent TRP channel blocker and a store operated Ca2+ entry (SOCE) inhibitor. SKF 96365 hydrochloride significantly inhibits hERG, hKCNQ1 hKCNE1, hKir2. 1 and hKv4. 3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF 96365 hydrochloride exhibits potent anti neoplastic activity by inducing cell cycle arrest and apoptosis in colorectal cancer cells. Product information CAS Number: 130495