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1 nM-10 μM) treatment for 1 hour causes a dose-dependent increase in cGMP levels in normal human trabecular meshwork (NTM) cells (average EC50=2
in the presence of 100 mM NaCl and 1 mM KCl
InChi: InChI=1S/C33H36N6O3S/c1-20-24(9-7-10-25(20)36-31(40)28-18-22-8-5-6-11-27(22)43-28)26-19-39(4)33(42)30(35-26)34-23-14-12-21(13-15-23)29-32(41)38(3)17-16-37(29)2/h7
Solubility: DMSO : 250 mg/mL (641
EML 425 9-Hydrazide 1 nM-10 μM) treatment forEML425 is a potent and selective CREB binding protein (CBP) p300 inhibitor with IC50s of 2. 9 and 1. 1 M, respectively. Product information CAS Number: 1675821 32 5 Molecular Weight: 440. 49 Formula: C27H24N2O4 Chemical Name: 1,3 dibenzyl 5 [(4 hydroxy 2,6 dimethylphenyl)methylidene] 1,3 diazinane 2,4,6 trione Smiles: CC1C=C(O)C=C(C)C=1C=C1C(=O)N(CC2C=CC=CC=2)C(=O)N(CC2C=CC=CC=2)C1=O InChiKey: LUGQBJDYUPNAQQ UHFFFAOYSA N InChi: InChI=1S C27H24N2O4 c1
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