AR-13324 analog mesylate drosoyasaponin I 3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15

3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15

and prevents AhR-mediated signaling

Zanin-Zhorov A

NCC1C=CC(=CC=1)C1=CC(=CC=C1)OC1=CC=NC(C#N)=N1

AR-13324 analog mesylate drosoyasaponin I 3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15AR 13324 analog mesylate is a small molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes. . Wang RF, et al. Effect of 0. 04% AR 13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan; 24(1): 51 4. . Levy B, et al. Ocular hypotensive safety and systemic absorption of AR 13324 ophthalmic solution in