KO-947 3-amine Smiles: CC(C)[C@@H](C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1)N1CCCNC1=O

Smiles: CC(C)[C@@H](C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1)N1CCCNC1=O

FOY-251 inhibits the proteolytic activity of prostasin

K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos

and does not potently inhibit PI3K

KO-947 3-amine Smiles: CC(C)[C@@H](C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1)N1CCCNC1=OKO 947 is a potent and selective inhibitor of ERK1 2 kinases. KO 947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling at low nanomolar concentrations. Product information CAS Number: 1695533 89 1 Molecular Weight: 355. 39 Formula: C21H17N5O Chemical Name: 1,5,6,8 Tetrahydro 6 (phenylmethyl) 3 (4 pyridinyl) 7H pyrazolo[4,3 g]quinazolin 7 one Smiles: