J147 - Neuroprotective Small Molecule. CAS# 1146963-51-0 Catalog No.:M60012-10S Epub 2017 Dec 28

Epub 2017 Dec 28

Akiyama T E

for which there is at least a 400-fold selectivity versus FGFR1

115(4):824-33

J147 - Neuroprotective Small Molecule. CAS# 1146963-51-0 Catalog No.:M60012-10S Epub 2017 Dec 28J147, CAS No. 1146963 51 0, is a potent and orally active neurotrophic molecule discovered based upon efficacy in multiple cellular models of age associated pathologies rather than exclusively amyloid metabolism. J147 is broadly neuroprotective, and active in six different assays that represent distinct neurotoxicity pathways related to aging and neurodegenerative diseases, with EC50 between 10 and 200 nM. It can also improve memory in normal rodents,