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InChi: InChI=1S/C17H18O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-7
Chemical Name: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide hydrate hydrochloride
BCAT-IN-1 (compound 8b) inhibits BCATm in human cells
shows high binding affinity to human Factor D with Kd value of 0
(S)-PFI-2 (hydrochloride) xypicolinic acid InChi: InChI=1S/C17H18O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-7(S) PFI 2 (hydrochloride) is the inactive enantiomer of (R) PFI 2 and may serve as a negative control. (R) PFI 2 is a cell permeable and potent SET7 9 inhibitor with IC50 value of 2 nM . Protein methyltransferases involve in the epigenetic regulation of gene transcription, silencing, chromatin structure establishment, maintenance, DNA repair, and replication. SET domain containing (lysine methyltransferase) 7 (SETD7) (SET9; SET7 9, KMT7) is a protein
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