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Smiles: CCOC1=CC(=CC=C1OCC)C1=NC(=NO1)C1=CC=CC2C(CCC=21)NCCO
1-1 µM final concentration in vitro and in cellular assays
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC
Kawamoto I
Dabrafenib - CAS# 1195765-45-7 size:2mg solid Smiles: CCOC1=CC(=CC=C1OCC)C1=NC(=NO1)C1=CC=CC2C(CCC=21)NCCODabrafenib, CAS No. 1195765 45 7, also known as GSK2118436 , is an orally bioavailable inhibitor of B raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B raf belongs to the the raf mil family of serine threonine protein kinases and plays a role in regulating the MAP kinase ERKs signaling
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