MI-503 367nfluenza Hemagglutinin (HA) Peptide It inhibits IDH1 R132H mutant

It inhibits IDH1 R132H mutant and R132C mutant in vitro with IC50 ~0

InChi: InChI=1S/C22H27N5O2/c1-15-12-26(13-16-5-3-2-4-6-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-7-9-29-10-8-17/h2-6

InChiKey: AIJTTZAVMXIJGM-UHFFFAOYSA-N

ClC1=CC(CNC2=NC3C=CC=CC=3NC32CCNCC3)=CC=C1

MI-503 367nfluenza Hemagglutinin (HA) Peptide It inhibits IDH1 R132H mutantMI 503 is a highly potent and orally bioavailable small molecule inhibitor of the menin mLL interaction. Product information CAS Number: 1857417 13 0 Molecular Weight: 564. 63 Formula: C28H27F3N8S Chemical Name: 4 methyl 1 [(1H pyrazol 4 yl)methyl] 5 [(4 {[6 (2,2,2 trifluoroethyl)thieno[2,3 d]pyrimidin 4 yl]amino}piperidin 1 yl)methyl] 1H indole 2 carbonitrile Smiles: CC1=C2C=C(C#N)N(CC3=CNN=C3)C2=CC=C1CN1CCC(CC1)NC1=NC=NC2SC(CC(F)(F)F)=CC=21