Futibatinib Catalog No.:M18482-C and/or liver cell necrosis

and/or liver cell necrosis

Compound E bloks β-amyloid(40)

C2HF3O2/c1-8-45(4)74(91(150)120-73(44(2)3)90(149)122-75(48(7)124)92(151)115-58(32-49-16-10-9-11-17-49)82(141)118-65(42-157)88(147)119-63(40-155)86(145)109-53(18-12-13-29-96)80(139)117-64(41-156)87(146)116-62(94(153)154)37-72(133)134)121-85(144)60(35-68(99)127)113-81(140)57(33-50-21-23-52(125)24-22-50)112-83(142)59(34-51-39-102-43-104-51)111-77(136)47(6)105-78(137)54(19-14-30-103-95(100)101)108-84(143)61(36-71(131)132)114-89(148)66-20-15-31-123(66)93(152)56(26-28-70(129)130)110-76(135)46(5)106-79(138)55(25-27-67(98)126)107-69(128)38-97

Ilginatinib maleate also inhibits Src-family kinases

Futibatinib Catalog No.:M18482-C and/or liver cell necrosisFutibatinib (TAS 120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor, with IC50s of 3. 9, 1. 3, 1. 6, and 8. 3 nM for FGFR 1 4, respectively. Futibatinib inhibits mutant and wild type FGFR2 with similar IC50s (wild type FGFR2=0. 9 nM; V5651=1 3 nM; N550H=3. 6 nM; E566G=2. 4 nM). Product information CAS Number: 1448169 71 8 Molecular Weight: 418. 45 Formula: C22H22N6O3 Chemical Name: 1 [(3S) 3 {4 amino 3 [2 (3,5