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treatment with sorafenib at 100 mg/kg once daily does not provide any benefit in vivo
basal and HER2+
2 uM in vitro :Castanospermine
Published 2018 Jul 5
PROTAC EED degrader-2 17259 treatment with sorafenib at 100PROTAC EED degrader 2 is a PROTAC targeting EED with a pKD of 9. 27. PROTAC EED degrader 2 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8. 11) targeting the EED subunit. Product information CAS Number: 2639882 69 0 Molecular Weight: 960. 13 Formula: C50H58FN11O6S Chemical Name: (2S, 4R) 1 [(2S) 2 (5 {3 [5 (5 {[(5 fluoro 2, 3 dihydro 1 benzofuran 4 yl)methyl]amino} [1, 2, 4]triazolo[4, 3 c]pyrimidin 8 yl) 6 methylpyridin 2
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