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GDC-0879 also shows EC50 values < 0
The metabolic activity of CMA07 and CMT-U27 cell lines is significantly decreased with 305 μM Oseltamivir phosphate treatment (p=0
10(4):268-72
Smiles: OC1=CC=CC2[C@@H]([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C3=CC(CO)=CC(O)=C3C(=O)C1=2
(R)-(+)-Etomoxir Sodium Salt rtine Maleate GDC-0879 also shows EC50 valuesEtomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT 1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPAR.