TAK-901 Size:Solid 2 mg Philos Trans R Soc Lond

Philos Trans R Soc Lond B Biol Sci

10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetat

Smiles: CC1=CC(=CC=C1OC1C=CN2N=CN=C2C=1)NC1=NC=NC2=CC=C(C=C21)NC1=NC(C)(C)CO1

is a cinnamic hydroxamic acid analogue with potential antineoplastic activity

TAK-901 Size:Solid 2 mg Philos Trans R Soc LondTAK 901 is a small molecule inhibitor of the serine threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK 901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to