BS-181 dihydrochloride enzamine Hydrochloride 2-bis(4-fluorophenyl)-2-phenylacetamide

2-bis(4-fluorophenyl)-2-phenylacetamide

Chemical Name: (2Z)-3-(cyclohexylamino)-2-(phenylmethylidene)-2

3109/01902148

Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+

BS-181 dihydrochloride enzamine Hydrochloride 2-bis(4-fluorophenyl)-2-phenylacetamideBS 181 dihydrochloride is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY 30237). BS 181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880 nM, 3000 nM and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS 181 dihydrochloride inhibits a panel of cancer cells growth (IC50=11. 5 M 37. 3 M) and induces cell apoptosis. BS 181 dihydrochloride has the potential for the research of cancer therapy. Product information