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MP-470 (10 μM) inhibits glycogen synthase kinase (GSK)3β activity
PubMed Central PMCID: PMC5352210
PubMed PMID: 19920929
PubMed PMID: 25712356
Telatinib (BAY 57-9352) c acid MP-470 (10 μM) inhibits glycogenTelatinib, aslo known as BAY 57 9352, is a potent and orally active VEGFR 2 and VEGFR 3 tyrosine kinase inhibitor. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Telatinib treatment was well tolerated. The observed single agent antitumor activity in heavily pretreated CRC patients was limited. Pharmacodynamic results are suggestive for the biological activity of telatinib justifying
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