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Molecular Weight: 3012
InChi: InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7
Development of the BET bromodomain inhibitor OTX015
CAS Number: 73360-56-2
ZLJ-6 Size:Contact [email protected] for quotation Molecular Weight: 3012IC50: 0. 73, 0. 31, and 0. 99 M for COX 1, COX 2, and 5 LO, respectively ZLJ 6 is a dual inhibitor of COX and 5 lipoxygenase (5 LO). Cyclooxygenase (COX) is an enzyme that is responsible for formation of prostanoids, such as thromboxane and prostaglandins such as prostacyclin. 5 lipoxygenase (5 LO) is the major source of leukotrienes. In vitro: ZLJ 6 was identified as a potent inhibitor of cyclooxygenase in human whole blood. It also inhibited the
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