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2ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3
InChiKey: IPAVKOYJGUMINP-CSMHCCOUSA-N
23-nonaen-24-ium chloride
56(5):1259-67
GNE-371 Catalog No.:M22638-C 2ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3GNE 371 is a potent and selective chemical probe for the second bromodomains of human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1 like, with an IC50 of 10 nM for TAF1(2). GNE 371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain family members. GNE 371 is also active in a cellular TAF1(2) target engagement assay (IC50=38 nM) and
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