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Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)
PubMed PMID: 20421638
169(2):855-862
RTI-118 (5-30 mg/kg
DHODH-IN-1 151rostaglandin E2 Bis-PEG5-NHS ester is a cleavableDHODH IN 1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH IN 1 is an inhibitor of pyrimidine biosynthesis pathway. Product information CAS Number: 1800296 63 2 Molecular Weight: 403. 40 Formula: C21H20F3N3O2 Chemical Name: 5 cyclopropyl 2 [4 (2,6 difluorophenoxy) 5 methyl 3 (propan 2 yloxy) 1H pyrazol 1 yl] 3 fluoropyridine Smiles: CC1=C(OC2C(F)=CC=CC=2F)C(=NN1C1=NC=C(C=C1F)C1CC1)OC(C)C InChiKey: