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2015 Aug 12
inhibits IκBα ubiquitination with IC50 ~5
3-c]pyridin-5-yl)-3-(benzyloxy)-1-oxopropan-2-yl)-2-methylpropanamide (2R
da Silva CR
R-GNE-140 - CAS# 2003234-63-5 size:2mg solid 2015 Aug 12R GNE 140, CAS No. 2003234 63 5, a novel potent lactate dehydrogenase (LDHA) inhibitor with IC50 3nM for LDHA and 5 nM for LDHB. In MIA PaCa 2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE 140, but could be resensitized to
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