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1007/s40265-019-01210-0
68(4):1162-9
Brusatol (NSC 172924) provokes the depletion of Nrf2 via a mechanism that is not dependent on Keap1 and the proteasomal and autophagic protein degradation systems
Smiles: C=CCNC1N=CN=C2C=CC(Br)=CC2=1
PKI-179 hydrochloride - CAS# 1463510-35-1 Catalog No.:M16656-C 1007/s40265-019-01210-0PKI 179 hydrochloride is a potent and orally active dual PI3K mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0. 42 nM for PI3K , PI3K , PI3K , PI3K and mTOR, respectively. PKI 179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI 179 hydrochloride shows anti tumor activity in vivo. Product information CAS Number: 1463510 35 1 Molecular Weight: 525. 00 Formula: C25H29ClN8O3
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