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IDH2-C100 was used at 1-5 µM in vitro and cellular assays
AdipoRon was administered orally to mice at 50 mg/kg once per day
2014 Dec 19
Pediatr Blood Cancer
SF-1670 - CAS# 345630-40-2 66054 IDH2-C100 was used at 1-5SF 1670, CAS No. 345630 40 2, is a specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor. SF 1670 specifically binds to the active site of PTEN inhibiting its activity with an IC50 value of 2 M. The innate immune responses can be enhanced and the severity of neutropenia related infection can be alleviated by augmenting phosphatidylinositol (3, 4, 5) trisphosphate in transfused neutrophils with PTEN inhibitor SF 1670,
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