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Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR)
the dramatic effect on T cell functions has been repeatedly demonstrated
InChi: InChI=1S/C22H22O10/c1-8-3-10-15(12(24)4-8)19(27)16-11(17(10)25)5-9(30-2)6-13(16)31-22-21(29)20(28)18(26)14(7-23)32-22/h3-6
There is negligible activity for G-5555 against the hERG channel with IC50 more than 10 μM in a patch clamp assay
Pyrotinib methylanthranilate Methyllycaconitine citrate is a specificPyrotinib (SHR 1258) is a potent and selective EGFR HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively. Product information CAS Number: 1269662 73 8 Molecular Weight: 583. 08 Formula: C32H31ClN6O3 Chemical Name: (2E) N [4 ({3 chloro 4 [(pyridin 2 yl)methoxy]phenyl}amino) 3 cyano 7 ethoxyquinolin 6 yl] 3 [(2R) 1 methylpyrrolidin 2 yl]prop 2 enamide Smiles: CCOC1C=C2N=CC(C#N)=C(NC3C=C(Cl)C(=CC=3)OCC3C=CC=CN=3)C2=CC=1NC(=O) C=C [C@H]1CCCN1C