ML-095 (hydrochloride) 22717 Smiles: COC1=CC(C[C@H]2CO[C@@H]([C@H]2CO)C2C=C(OC)C(=CC=2)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=CC=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Smiles: COC1=CC(C[C@H]2CO[C@@H]([C@H]2CO)C2C=C(OC)C(=CC=2)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=CC=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Smiles: COC1C=CC(CN2C(=NN=C2CCC2C=CC=CC=2)[C@@H](CC2=CNC3C=CC=CC2=3)NC(=O)CN)=CC=1

79 and 51 nM in human

bacterial replication

ML-095 (hydrochloride) 22717 Smiles: COC1=CC(C[C@H]2CO[C@@H]([C@H]2CO)C2C=C(OC)C(=CC=2)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=CC=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1OML 095 (hydrochloride) is a specific PLAP inhibitor . Alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. There are three isozymes of alkaline phosphatases: placental alkaline phosphatase (PLAP), intestinal alkaline phosphatase (IAP), and tissue non specific alkaline phosphatase (TNAP). Placental alkaline phosphatase (PLAP) is highly