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the anti-MM activity of ACY-1215 in combination with bortezomib was confirmed using 2 different xenograft SCID mouse models
including all isoforms of PI3K (less than 25% inhibition when tested at 1 μM against Invitrogen kinase panel)
CC(C)(C)C1=CC(NC(=O)NC2C=CC(=CC=2)C2=CN3C(=N2)SC2=CC(=CC=C32)OCCN2CCOCC2)=NO1
MS436 was used at 10-100 µM final concentration in various in vitro assays
NU7026 - CAS# 154447-35-5 60111 the anti-MM activity of ACY-1215NU7026, CAS No. 154447 35 5, is a novel specific DNA PK inhibitor with IC50 of 0. 230. 01 M, also inhibits PI3K with IC50 of 133 M. Product information CAS Number: 154447 35 5 Molecular Weight: 281. 31 Formula: C17H15NO3 Chemical Name: 2 morpholino 4H benzo[h]chromen 4 one Smiles: O=C1C=C(OC2=C1C=CC1=CC=CC=C12)N1CCOCC1 InChiKey: KKTZALUTXUZPSN UHFFFAOYSA N InChi: InChI=1S C17H15NO3 c19 15 11 16(18 7 9 20 10 8 18)21 17 13 4 2 1 3 12(13)5 6 14(15)17 h1