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6-maleimidohexanoic acid active esters
MOA study showed P7C3 could bind nicotinamide phosphoribosyltransferase (NAMPT)
(2011) 53rd ASH Annual Meeting and Exposition
The inhibition of USP7 is predicted to destabilize HDM2 and stabilize p53
EPZ-5676 - DOT1L inhibitor. CAS# 1380288-87-8 60160 6-maleimidohexanoic acid active estersEPZ 5676, CAS No. 1380288 87 8, is a highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S adenosylmethionine. It inhibits proliferation of MLL AF4 rearranged cell line MV4 11 with an IC50 of 9 nM. It reduces H3K79 dimethylation with a cellular IC50 of 2. 6 nM in MV4 11 cells. EPZ 5676 has over 10, 000 fold selectivity against other HMTs. Its superior potency is
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