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Voorhees P
Thirunarayanan N
04 μM in MG63 cell lines
including all members of the AKT family that had not been previously detected by other broad-spectrum kinase inhibitors
PF-03814735 - CAS# 942487-16-3 Catalog No.:M10382-2 Voorhees PPF 03814735 is an orally bioavailable, ATP competitive, reversible small molecule Aurora kinase inhibitor with potential antineoplastic activity. Aurora kinase inhibitor PF 03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine threonine kinases that play essential roles in mitotic checkpoint control during
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