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20)/b13-7+
but not the iron chelator desferal
potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models
2009 Jan 5
Masitinib Size:2mg solid 20)/b13-7+Masitinib, also known as AB1010, is an orally bioavailable and multi targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild type and mutated forms of the stem cell factor receptor (c Kit; SCFR); platelet derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor
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