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WO 2010022355 A1 20100225
Smiles: O
CPI-444 is a potent
EC50 = 490 nmol/L)
BAY-985 Catalog No.:M7451-2 WO 2010022355 A1 20100225BAY 985 is a potent and highly selective TBK1 IKK inhibitor. BAY 985 shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKK(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK MEL 2 cells (IC50 = 900 nM). Product information CAS Number: 2409479 29 2 Molecular Weight: 553. 58 Formula: C27H30F3N9O Chemical Name: 1 (4 {(1R) 1 [2 ({6 [6
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